Mark Henderson, Science Editor
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Parliament’s decision to approve research using “admixed embryos” that contain human and animal material is not going to lead to immediate medical breakthroughs.
Cells taken from “cytoplasmic hybrids” or “cybrids” - the main type of admixed embryos - are never likely to be transplanted into sick patients. Any insights that they might offer into diseases such as Parkinson’s and Alzheimer’s, too, are probably years away.
The outcome of last night’s vote, however, is still a watershed for British science. First, it clears the way for experiments that could advance understanding of several devastating conditions, and the prospects of using all types of stem cell, embryonic and adult, in therapies.
Just as importantly, it confirms the value placed on free scientific inquiry in Britain, where regulation rather than prohibition is deemed the proper approach to ethically contentious research.
As cybrids are supported by all the country’s leading scientific institutions, a ban would have suggested that this considered consensus matters less to Parliament than the vocal concerns of a religious minority. That would have led researchers in this field, and perhaps in others, too, to question whether the UK remains a good place to pursue a scientific career.
By placing the nuclei of human cells into empty cow eggs, scientists hope to create cell models of diabetes or motor neuron disease, using DNA from patients with these disorders. These could be used to investigate how these conditions progress, and to develop and test new drugs.
Human eggs could be used for these experiments, but as these cannot be donated without risk to women, they are always going to be in short supply. Animal eggs, which are plentiful, can now be used.
Scientists do not know yet if the cybrid approach will work, though early indications are positive. That, though, is why they want permission to do these experiments – without them, we will never find out.
Much was said in the debate about the benefits of adult stem cells, which are already used to treat dozens of conditions. MPs who oppose embryonic research also talked up the promise of induced pluripotent stem (IPS) cells, made by reprogramming adult skin cells into a versatile embryo-like state, and stem cells from umbilical cord blood.
All these approaches are exciting, but they are no reason not to proceed with embryonic stem-cell and cybrid research. This is a young field, and it is too early to pick winners. That is why the Medical Research Council splits its budget roughly equally between embryonic and adult stem-cell research.
Cybrid and embryonic research is actually likely to assist adult stem-cell research: parallel studies can reveal important details about how all these types of cell give rise to more specialised tissue.
IPS cells may well be the future of regenerative medicine, as they do not require the destruction of embryos, but they would not exist without the past decade of embryonic work. They are also not close to being ready for therapeutic use. As cybrids also involve reprogramming of the nucleus, they could inform new approaches to turning back the clock on adult tissue.
The defeat of the move to ban true hybrids is also welcome. Though no experiments with these embryos are yet planned, they will help research into male infertility, in which scientists can study how sperm works without needing scarce human eggs.
The vote is significant for another reason: it will encourage scientists to speak out more about their research. The Government intended to ban cybrids, but changed its mind when stem cell experts such as Stephen Minger and Lyle Armstrong took time to say what they planned to do, and why.
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To Tom of London:
You proceed on the premise that one should find 'using' human embryos acceptable, in the first place: so I expect that James is not happy with the move to 'use' monsters' embryos instead. I am certainly not!
Nicholas Storey, Rio de Janeiro, Brasil
Whether these hybrids are created with human gametes or not seems, frankly, beside the point. Modern Britain, alone, apparently has seen fit to license the creation of the chimaera and one is reminded of the expressly 'well-intentioned' British and Nazi eugenists of the first half of the 20th C.
Nicholas Storey, Rio de Janeiro, Brasil
Welcome to the world of "test-tube bestiality"!
Kenneth Barnes, Oxford, United Kingdom
To James, Ave Maria FL:
So Is you hair innocent? Cause the core of the cell which constitutes the human DNA part of the equation and implanted into the emptied cow egg could be taken from one of them. This method is an opportunity not to use human embryos, doesn't that make you happy?
Tom, London,
Maybe Britain will become the first Island of Dr. Moreau? Never mind, It'll be an Islamic Republic long before that.
David Sanger, Detroit, USA
So, let me see if I have this correctly: It is BAD to chase down suicidal islamic extremists who kill innocent men, women and children; but, it is OK to encourage and fund medical experimentation resulting in splicing an innocent human being with an animal. A sad day for not-so-Great Britain.
James, Ave Maria FL, United States
Both G Brown and D Cameron backed this controversial human-animal embryo research. Co-incidentally both of them have produced a child with a disabling illness they say they'd like to see a cure for. Which begs the question have they donated any of their wives' eggs or their own sperm for research
N Caton, Preston, England UK
Actually jv from cornwall an embryo will not form into a thinking being if left alone! If you took the cells that are usually used for this research (rejects from IVF) and left them alone in your culture dish they would be inviable in a very short time indeed!
Liv, Oxford, UK
Not only Scolding was ignored re: the HFE Bill. Select Cttee. just ignoredProfessor Anand fetal pain studies (who revolutionised understanding of pain in newborn). They preferred 2005 JAMA review co-authored by Sue Drey, director of large abortion clinic and others who do not do fetal pain research!
sara allen, london,
There just has to be some other way to conduct similar research without creating and destroying malformed life. Can't anyone else see that? Religion aside, it's an ethical debate. This isn't scraping some cells off your arm. Those cells won't form into a thinking being if left alone. The embryos do.
jv, Cornwall,
"No miracle cures tomorrow." Isn't it strange how that wasn't mentioned in the run up to this debate. Perhaps new labour were worried that the profits of their industry friends would be damaged.
Denis, Colchester,
Opponents of human animal hybrids have been much maligned by a tiny but influential band of anti-religious extremists like Des. The scientists who oppose this research are eminent and worth listening to - Neil Scolding, anyone? - but strangely never get mentioned by the ultra-partisan Mark Henderson
Justine, London,
God will not put up with this insane behavior by mankind.count on it.I see no purpose of this other than tinkering with Gods creation and it will most certainly go awry.
Don't be fooled by this ,saying it is for curing sicknesses in this ungodly manner... the brits in gov't playing the fools game.
larry evans, ottawa, USA
It couldl be the first step towards developing a fully-fledged scientific ethics, so that it will be left up to researchers to decide how far to push their investigations. Tonight's deliberation is a true step forward for science in Britain.
Roberto Ruggiu, Rome, Italy
The scientists involved in this research have been much maligned by a small but influential band of religious extremists. The scientists know that there will be no miracle cures tomorrow, but they also know the benefit of not closing avenues of research. We need treatments for many diseases.
Des, Edinburgh,